
Two years after the events of 428: Fūsa Sareta Shibuya de, Maria Ōsawa and Minoru Minorikawa are dispatched as reporters to Shanghai in order to cover the upcoming Shanghai NBCR International Anti-Terrorist Conference. Prior to their current assignment, both Maria and Minoru were survivors of the Shibuya bio-terrorism incident, where Maria was kidnapped by terrorists and was infected by the Ua virus but was cured by her scientist father using an experimental anti-Ua virus vaccine. Maria is later saved by her friend, a Middle Eastern girl named Canaan after being targeted for death by masked assassins on her first day in Shanghai after she befriended her in the Middle East prior to the events
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